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Fig. 11. Serotonin increases the strength and frequency of the heartbeat in isolated
hearts (N=7). (A) Means of ratios of the amplitude of the contraction
in the presence and absence of serotonin (5-HT) for each preparation are shown
as a function of temperature. There are no statistically significant
differences in amplitude across temperature (P=0.40). (B) Means of
ratios of the frequency of the heartbeat in the presence and absence of
serotonin for each preparation are shown as a function of temperature. There
are no significant differences in heart rate across temperature
(P=0.69). (C) Phase plots for heartbeats recorded in the absence
(control) and presence of serotonin show similar shapes. Each trace shows the
rate of change of force (y-axis) as a function of the force of the
contraction (x-axis) for heartbeats recorded over 1 min at 2°C.
In this experiment serotonin increased contraction amplitude at 2°C by
39.6%.
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