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Figure 6


Fig. 6. Effect of hypercapnic acidosis and Na+/K+ ATPase-pump inhibition on intracellular Na+ levels. (A) Typical recording of [Na+]i in the continued presence of 5 µmol l–1 cariporide. Switching from a 5% to a 12% CO2 buffered solution had no effect on Na+i levels, whereas addition of the Na+/K+ ATPase pump inhibitor, ouabain at 10 µmol l–1 during hypercapnic acidosis, substantially increased [Na+]i. (B) Overall results showing mean sodium-binding benzofuran isophthalate (SBFI) fluorescence values, indicating the lack of effect of hypercapnic acidosis on Na+i levels and the significant increase produced by ouabain. Values are means ± s.e.m., N=5 cells. *P<0.05 with respect to values before hypercapnia.





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