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Figure 4


Fig. 4. Effect of hypercapnic acidosis on calcium transient (CaiT). (A) Top, a typical continuous recording of myocyte cell length during hypercapnic acidosis. Below, actual tracings of the individual twitch contractions and the Fura-2 fluorescence transients at the times indicated by letters a–c on the continuous chart. (B) Overall results of the effect of acidosis on CaiT, shortening and relaxation time of both parameters. The results indicate that during the recovery there is an increase in diastolic and peak systolic [Ca2+]i with a prolongation of the CaiT (results from five different myocytes). *P<0.05 vs values before hypercapnia.





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