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Figure 3


Fig. 3. Effect of persistent hypercapnic acidosis on contractile recovery in the presence and absence of the Na+/H+ exchanger (NHE) inhibition. (A) Isolated myocytes. During hypercapnic acidosis, contractility followed a pattern similar to that of ventricular strips, reaching control values after an initial fall. In spite of abolishing pHi restitution with the NHE inhibitor cariporide (5 µmol l–1), the inotropic recovery was not cancelled. (B) Ventricular strips. The presence of cariporide (5 µmol l–1) did not modify the inotropic response of the toad ventricle to acidosis. There were no statistically significant differences between control and cariporide-treated preparations. Data are means ± s.e.m. of five experiments.





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