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Figure 6


Fig. 6. Activation properties of CionaKv4 and an N-terminal deletion mutant of CionaKv4 (ntCionaKv4) in the presence and absence of CionaKChIP. (A) Comparison between current-voltage relationships for CionaKv4 alone and in the presence of CionaKChIP (Ai), CionaKv4 and ntCionaKv4 (Aii), and ntCionaKv4 alone or with CionaKChIP (Aiii). N=17. (B) Comparison between the time constants of macroscopic activation ({tau} activation)-voltage relationships for CionaKv4 alone or in the presence of CionaKChIP (Bi), for CionaKv4 and ntCionaKv4 (Bii), and for ntCionaKv4 alone or with CionaKChIP (Biii). Solid curves represent single exponential fits to these relationships. N=12. (C) Comparison between normalized peak conductance-voltage relationships for CionaKv4 alone or with CionaKChIP (Ci), for CionaKv4 and ntCionaKv4 (Cii), and for ntCionaKv4 alone or with CionaKChIP (Ciii). N=17. Solid curves represent first order Boltzmann fits of the averaged data. ntCionaKv4 symbolizes CionaKv4 channels lacking N-terminal amino acids 2-32. Values are means ± s.e.m.





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