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Fig. 3. Alignment and sequence comparison between CionaKChIP and
representatives of the four vertebrate KChIP isoforms. The deduced amino acid
sequence of CionaKChIP and selected KChIPs belonging to the four
mammalian isoforms were aligned using T-Coffee software
(Notredame et al., 2000).
KChIP subunits and GenPept. accession numbers were: CionaKChIP,
AAS00647; KChIP1a, AAL12489; KChIP2a, AAF81755; KChIP3, Q9Y2W7; KChIP4b,
NP_079497. Residues that are identical for at least three of the five KChIPs
are shown in reverse lettering (white on black). The positions of the four
EF-hands are underlined and labelled below the alignment. X,Y,Z,-Y,-X,-Z are
the residues that coordinate Ca2+
(Bairoch and Cox, 1990). Arrows
indicate exon/intron boundaries for CionaKChIP only. Putative
phosphorylation sites for protein kinase C (PKC) are indicated by filled
circles.
