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Fig. 2. Alignment and sequence comparison of Kv4 channels from diverse metazoans.
Alignment of the deduced amino acid sequence of the three mammalian Kv4
isoforms (Kv4.1, Kv4.2 and Kv4.3), their tunicate homologues
(CionaKv4 and TuKv4), lobster Shal (lShal) and jellyfish
Shal (jShal). T-Coffee software
(Notredame et al., 2000) was
used to align these sequences, with the following GenPept. accession numbers:
CionaKv4, AAS00646; TuKv4, BAC53863; Kv4.1, 27436981; Kv4.2, 9790093;
Kv4.3, 6653655; lShal, AAA81592; jShal, AAB39750. Residues that are identical
for at least four of the seven channels are shown in reverse lettering (white
on black). Membrane-spanning domains S1-S6, the pore region and the N terminus
are underlined. Arrows indicate exon/intron boundaries for CionaKv4
only. The di-leucine motif is labelled. Putative phosphorylation sites for
cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) are indicated
by filled circles and open circles, respectively.
