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Fig. 7. Treatment of pre- and pro-metamorphic larvae with exogenous T3 induces lateralized behaviors and symmetric frontal bone development. Although untreated pre- (B) and pro-metamorphic (I) larvae initially have narrower right frontal bones compared with left, T3 treatment induces a bilaterally symmetric condensation of both frontals so they become similarly thick (D,K). T3 treatment of pre-metamorphic larvae induces settling (E) and tilted swimming (F,G) behaviors in the absence of eye migration. (A,B) Late pre-metamorphosis (14 d.p.f.), untreated; (C,D) late pre-metamorphosis after 100 nmol l^-1 T3 72 h; (E) settled bilaterally symmetric larvae following T3 treatment (view from above); (F,G) swimming larva after T3 treatment (frontal view). Late pro-metamorphosis (20 d.p.f.), untreated (H,I); late pro-metamorphosis after 100 nmol l^-1 T3 72 h (J,K). Cartilage (Alcian Blue) (A,C,H,J); calcein stain for bone (B,D,I,K). Right supraorbital bar (red arrow); frontal bones (white arrow); left and right parietal bones (LP, RP). Red structures in G denote relative position of the labyrinths. Bars, 0.2 mm.

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