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Figure 3


Fig. 3. Time-dependent properties of INa in atrial and ventricular myocytes of the rainbow trout heart. (A) Development of rested-state inactivation of INa. Increased duration of the prepulse at -80 mV reduces INa elicited by the test pulse to -20 mV for 30 ms. (B) Recovery of INa from inactivation (reactivation). The amplitude of INa elicited by test pulses to -20 mV for 100 ms increases as a function of the time interval between the prepulse P1 and the test pulse P2. Voltage protocols of INa are shown at the top, representative recordings in the middle and mean (± s.e.m.) results from 9-14 myocytes at the bottom. Asterisks show a significant difference (P<0.05) between atrial and ventricular myocytes.





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