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Figure 3


Fig. 3. Sequence comparisons of complete (or near-complete) metazoan monoamine transporter sequences obtained from BLAST searches online and a Lumbricus terrestris OAT sequence (NCBI accession #DQ813341) from this study. The dendrogram confirms our tentative groupings based on the presence or absence of certain diagnostic amino acid residues in the partial transporter sequences (Fig. 1). Note that protostome OATs and deuterostome DATs/NETs form a single cluster (MAT). A NET-like gene is apparently lacking from protostome genomes and an OAT-like gene from deuterostome genomes such as echinoderms and chordates. The NCBI nucleotide and protein accession numbers and other genome resources used are listed in supplementary material Table S2. The scale bar shows evolutionary distance in number of substitutions per site.





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