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Figure 4


Fig. 4. Severe hypoxia decreases excitatory GABAergic neurotransmission in the Lymnaea central ring ganglia. (A) Example traces demonstrating the change in action potential (AP) firing frequency produced by puffing 500 µmol l-1 GABA (at arrow) onto the central ring ganglia. In normoxia (top trace) GABA produced an increase in AP firing frequency. Switching from normoxia to hypoxia decreased the excitatory response to GABA (lower trace). (B) Bar graph summarizing the percentage change in AP firing frequency and postsynaptic potential amplitude induced by puffing 500 µmol l-1 GABA onto both normoxic and hypoxic central ring ganglia.





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