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Fig. 2. Severe hypoxia decreases neuronal activity. (A) No significant changes in
the action potential (AP) frequency were observed in normoxic neurones
throughout the entire recording period (black bars; N=9,
P=0.935 paired t-test). After switching from normoxia to
severe hypoxia, AP frequency decreased significantly (grey bars; N=9,
P=0.001 paired t-test). (B) Example traces of AP frequency
during normoxia and 10 min after the switch to severe hypoxia.