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Figure 2


Fig. 2. Depression of force and stiffness of a maximally Ca2+-activated skinned anterior byssus retractor muscle (ABRM) fibre bundle by 10 mmol l-1 orthovanadate (Vi) and subsequent further depression by moderate alkalization. (A) Original recording of force and stiffness during changes of solutions as indicated. The force spikes are induced by repetitive rectangular stretches of 20 ms in duration and 0.1% L0 in amplitude. The broken line shows an experiment at pH 7.4. The insets show experiments on another ABRM fibre bundle; here force transients were induced by rectangular length changes of 0.2% L0 at different stages of the experiment. (B) Diagram showing the stiffness/force relationship of the experiment of Fig. 2A. Grey squares, Ca2+ activation; open circles, Vi; solid circles, moderate alkalization (change from pH 6.7 to pH 7.4) in the presence of Vi. The arrows indicate the time course of the experiment. (C,D) Data from similar experiments carried out at pH 7.4 (C) or in the presence of 100 µmol l-1 cAMP and 2 µmol l-1 cyclosporine A (CsA; D). Grey squares, Ca2+ activation; open circles, Vi application.





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