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Figure 3


Fig. 3. The effects of hypoxia (N2) and H2S are mutually competitive. (A) Individually, N2 and H2S produce similar contraction of lamprey dorsal aorta (DA; normalized to 80 mmol l–1 KCl contraction=100%) while in the presence of N2, H2S (3x 10–4 mol l–1) relaxes and in the presence of H2S, N2 contractions are significantly (P≤0.05; N=8 vessels) reduced. (B) In norepinephrine (NE; 10–6 mol l–1) pre-contracted rat thoracic aortas initial exposure to hypoxia (N2; top trace) or H2S (3x10–4 mol l–1; bottom trace) produces a typical relaxation, whereas subsequent application of either H2S (top) or hypoxia (bottom) results in either a slight contraction or no response. (C) In U-46619 (10–6 mol l–1)-contracted bovine pulmonary arteries, 3x10–4 mol l–1 H2S relaxes a pre-existing N2 contraction and N2 relaxes a pre-existing H2S contraction. H2S is lost from continuously aerated baths in C after which normal hypoxic contractions are restored. Values are means ± s.e.m., N=8 vessels; horizontal and vertical scale bars in B and C = 10 min and 0.5 g, respectively.





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