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Figure 1


Fig. 1. The response of isolated vessels to hypoxia (N2) or H2S (1 mmol l–1) is temporally and spatially similar, but vessel-specific. (A) Lamprey dorsal aorta (DA), (B) rat thoracic aorta (TA), (C) rat pulmonary artery (PA) pre-contracted with 10–6 mol l–1 norepinephrine (NE), (D) bovine pulmonary artery (PA) pre-contracted with 10–7 mol l–1 U-46619. A slight relaxation of bovine PA often precedes the hypoxic contraction; the H2S contraction appears mono-phasic, but it also is multi-phasic (see Fig. 2). Horizontal lines=10 min; vertical lines=0.5 g tension; W=wash. (1), (2) and (3) in C, indicate stages in the multiphasic response. (A) N2 trace adapted from (Olson et al., 2001), with permission; (C) H2S trace adapted from Dombkowski et al. (Dombkowski et al., 2005), with permission.





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