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Figure 6


Fig. 6. Effects of inhibitors of H2S synthesis on hypoxic (N2) relaxation of pre-contracted bladders. The cystathionine {gamma}-lyase inhibitor, D,L-propargylglycine (PPG; 20 mmol l-1) significantly decreased a N2 relaxation of 10 µmol l-1 carbachol-pre-contracted bladders and a mixture of PPG and the cystathionine ß-synthase inhibitor, amino-oxyacetic acid (AOA; 1 mmol l-1) significantly inhibited N2 relaxation of both 80 mmol l-1 KCl- and 80 mmol l-1 KAc-pre-contracted bladders (N=4 for all experimental groups; N=8 for controls). Values are means ± s.e.m. *Significantly different from the respective control; {dagger}significantly different from all other conditions.





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