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Figure 4


Fig. 4. Model for downregulation of myosin heavy chain (MHC) gene expression in space. This downregulation is due to a reduction in the level of transcripts encoding the transcription factors that regulate body-wall and pharyngeal MHC expression. Gene expression is influenced by microgravity at the level of transcription, independent of the differences between MHC isoforms and these transcription factors in tissue expression and function.





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