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Figure 5


Fig. 5. IP3 gated internal stores do not contribute to CBF excitation pathway. (A) CBF excitation caused by 100 µmol l-1 dopamine (DA) in CBF explants either bathed in FSW (open squares, N=5) or SW including 1 µmol l-1 of the IP3 inhibitor xestospongin C (Xesto; filled circles, N=5). (B) Comparisons of percent change in CBF with and without 1 µmol l-1 xestospongin C show it has no effect on dopamine or TPep-NLS (TPep) induced CBF excitation. 100 µmol l-1 Dopamine (N=5, P≤0.27) and 10 µmol l-1 TPep-NLS (N=5, P≤0.06) induced CBF excitation in a bath containing 1 µmol l-1 xestospongin C was indistinguishable from excitation induced by either alone.





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