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Figure 4


Fig. 4. Ca2+ release from stores contributes to the excitation of CBF. (A) Caffeine stimulated CBF. Both 1 mmol l-1 (open circles, N=5, P≤0.001) and 10 mmol l-1 (filled squares, N=6, P≤0.0003) caffeine increases CBF, however, the effects of 1 mmol l-1 caffeine decline over time. (B) Caffeine (Caff) excitation is reduced by the ryanodine receptor blocker dantrolene (Dant). 10 mmol l-1 Caffeine (N=6) induced CBF excitation is significantly reduced in 50 µmol l-1 dantrolene (N=7, P≤0.00004). 100 µmol l-1 dopamine and 10 µmol l-1 TPep-NLS excitation is also reduced by 50 µmol l-1 dantrolene (N=6, P≤0.0002; N=6, P≤0.00009, respectively). *Significant change from mean basal levels.





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