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Figure 3


Fig. 3. Ca2+ influx is necessary for increases in CBF. (A) Zero Cl- bath (filled circles) excites CBF (N=5, P≤0.001), and the effect does not diminish over time. The excitatory effect is abolished (N=5, P≤0.10 compared to control) when 50 µmol l-1 nifedipine (Nif; open squares) is included in the bath solution. (B) Excitation induced by 100 µmol l-1 dopamine (DA) and 10 µmol l-1 TPep-NLS (TPep) is also dependent on Ca2+ influx. Zero external Ca2+ (N=5, P≤0.008) and 50 µmol l-1 nifedipine (N=5, P≤0.003) both significantly reduce dopamine excitation. Similarly, zero external Ca2+ (N=5, P≤0.00009) and 50 µmol l-1 nifedipine (N=6, P≤0.01) also significantly reduce TPep-NLS excitation. *Significant change from mean basal levels (A) or significant reduction from stimulated levels (B).





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