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Figure 12


Fig. 12. Model of transmitter and neuropeptide action on CPE cells. Binding of dopamine or TPep-NLS to a receptor leads to a reduction in ICl(Ca) and I(Cl-)leak, leading to an increase in CBF. We hypothesize that I(Cl-)leak is carried by the same CaCC channels as the ICl(Ca), thus a single action by dopamine or TPep-NLS will block both. The blockage of the Cl- currents may lead to a depolarization of the cell, the signal necessary for Ca2+ influx. Pluses indicate molecules or actions that increase current size or beating rate, minuses represent inhibitory molecules or actions.





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