|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 2. Plasticity of glycogen metabolism in astrocytes. Activation of
c-AMP-dependent intracellular signaling by a restricted set of
neurotransmitters (noradrenaline, vasoactive intestinal peptide, adenosine)
results in a short-term (seconds to minutes) effect, i.e. glycogenolysis, and
in a delayed (hours) transcriptionally regulated action, i.e. glycogen
resynthesis. This long-term plastic response triggers the induction of
expression of a coordinated set of genes involved in glycogen resynthesis such
as the transcription factors C/EBP, and the genes encoding for the enzymes
glycogen synthase and protein targeting to glycogen.
|
