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Fig. 6. Metaplastic inhibition of the late phase of long-term potentiation (L-LTP).
(A) Transient depression was observed after 5 Hz low-frequency stimulation for
3 min (LFS) was applied to area CA1 of hippocampal slices from B6 mice.
However, fEPSP slopes recovered within 7 min after the end of LFS (open
circles). Sample fEPSP traces from one experiment are shown; these were
recorded 15 min before (a), during (b), immediately after (c), and 20 min
after (d) LFS. (B) Prior LFS at 5 Hz does not affect early LTP induced by a
single 100 Hz train. Control slices (open squares) generated LTP that was
similar in magnitude and time course to LTP induced in slices that received
LFS prior to tetanization (solid circles). Inset: sample fEPSP traces from one
experiment, measured 10 min before and 60 min after E-LTP induction. (C) Four
successive trains of 100 Hz, spaced 5 min apart, induced robust L-LTP in
control slices (open squares) and in slices that received a brief prior
episode of LFS (5 Hz, 30 s; solid triangles). No L-LTP was seen in slices that
received more prolonged LFS (5 Hz, 3 min; solid circles) prior to HFS. Inset:
sample traces from an experiment, measured 10 min before (Control) and 2 h
after L-LTP induction. (D) Increasing the time interval between LFS and L-LTP
induction abolishes anterograde metaplasticity of L-LTP. Defective L-LTP was
observed when LFS was applied 20 min before L-LTP induction (solid circles).
By contrast, normal L-LTP was seen when the time interval between LFS and HFS
was extended to 40 min (solid triangle). Adapted from
(Woo and Nguyen, 2002).
(Copyright 2002, Cold Spring Harbor Laboratory Press, used with
permission.)
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