|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 5. Spike discharge properties and glutamatergic receptor currents of CA1
pyramidal neurons are not strain dependent. (A) Membrane excitability: plot of
the number of action potentials produced during a 1 s current pulse
versus current amplitude in each of the four mouse strains. (B) Spike
frequency accommodation: plot of spike number (order in a train)
versus delay from onset of current injection. These are averages of
fifth-order polynomial curve fits of data obtained from B6 (N=13
cells) 129/SvEms (N=28), DBA (N=14) and CBA (N=21)
neurons. (C) Sample traces showing spike frequency accommodation in B6 and
129/SvEms cells. Current injections of 300 pA were used to elicit spiking. (D)
Left: ratios of N-methyl-D-aspartate (NMDA) to non-NMDA
glutamatergic currents were not significantly different between strains (B6,
N=14 cells; 129/SvEms, N=12; DBA, N=5; CBA,
N=5). Right: a current–voltage plot comparing the voltage
dependence of glutamatergic currents measured in B6 and 129/SvEms neurons.
Taken from (Nguyen et al.,
2000b). (Copyright 2000, The American Physiological Society, used
with permission.)
|
