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Fig. 2. Different phases of long-term potentiation (LTP). (A) The early phase of
LTP (E-LTP; solid circles) is usually induced by one train of high frequency
stimulation (HFS; arrowhead) and lasts 1–2 h. A more enduring, late
phase of LTP (L-LTP) is induced by three or more trains of HFS (open circles)
and is associated with larger amplitudes and steeper initial slopes of fEPSPs
for a longer period of time. Note the flat, stable plateau of elevated fEPSP
slopes, which is LTP. (B) Different phases of LTP have different mechanisms.
E-LTP involves covalent modifications of pre-existing molecules, whereas L-LTP
requires transcription and de novo protein synthesis. Adapted from
(Woo, 2003).
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