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Fig. 6. Time-course of the muscular exercise response in (A) normoxia and (B)
hypoxia. Untrained male subjects exercised for 30 min at the aerobic threshold
on a bicycle ergometer while breathing normoxic (21% O2) or hypoxic
air (13% O2, N=6/group). Biopsies were harvested during
the time-course of recovery from this single bout of exercise. Total RNA was
isolated and subjected to expression profiling using custom-made microarrays
(Fluck et al., 2005a;
Schmutz et al., 2006).
Transcript signals were related to the internal 28S rRNA reference and
analyzed for statistical significance using a Friedman ANOVA. The significant
changes of selected transcripts related to the oxidative pathway, such as
fatty acid transport, beta oxidation and mitochondrial respiration, are shown
in A and B. Significantly altered mRNA levels throughout the time-course of
recovery are underlined. Unaffected transcript levels of the main cytoskeletal
factors titin and desmin demonstrate the specificity of effect.
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