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Fig. 1. Concept of the integration of physiological stimuli in phenotypic
responses. Homeostatic perturbations such as those induced by exercise in
muscle are integrated via signaling pathways into alterations in gene
transcription. The diffusible gene copies produced then provide the message
for the instruction of muscle tissue remodeling via translation and
assembly of the encoded proteins. Based upon this relationship it is
hypothesized that the systematic exploration of differences in transcript
levels relative to phenotypic adjustments arising from the impact of exercise
will reveal the strategy underlying muscle plasticity.
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