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Figure 3


Fig. 3. Effect of agonist-induced depletion of cytosolic Ca2+ stores on tBHP-evoked Ca2+ increase in pancreatic acinar cells. Cells were perfused with either 1 nmol l-1 CCK-8 (A) or 1 µmol l-1 thapsigargin (TPS) (B) in Ca2+-free medium, followed by 1 mmol l-1 tBHP. Traces are representative of 74 and 58 such cells taken from 12 and 10 different experiments, respectively. (C) Histogram of the mean post-stimulus [Ca2+]c under different experimental conditions in 5-12 independent experiments. Values are means ± s.e.m. *P<0.05.





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