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Fig. 1. tBHP-evoked [Ca2+]c increase in isolated rat
pancreatic acinar cells. Cells were perfused with 1 mmol l-1
tBHP in (A) normal-Ca2+ or (B) Ca2+-free
(containing 1 mmol l-1 EGTA) medium. (C) Cells were perfused with 1
mmol l-1 tBHP followed by 2 mmol l-1 DTT in
Ca2+-free medium. Traces are representative of 61 and 53 such cells
taken from 10 and 8 different experiments, respectively. (D) Histogram
represents the mean post-stimulus [Ca2+]c under
different experimental conditions of 8-10 independent experiments. Values are
means ± s.e.m. *P<0.05.