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Fig. 2. (A) Maximum aerobic capacity (VO2max), (B) carbon dioxide production, (C) respiratory exchange ratio at VO2max (RER=VCO2/VO2max) and (D) maximum running speeds, measured in S and C mice (N=35 and 24, respectively) during forced exercise on a treadmill with a hypoxic (14% O2), normoxic (21% O2) or hyperoxic atmosphere (30% O2). Values are shown as adjusted means ± s.e.m. Statistical differences between hypoxic, normoxic and hyperoxic trials are shown in lowercase letters; effects of selection history for each trait at a given PO2 are shown in Table 2; overall effects of selection on the entire dataset (i.e. across PO2) are listed in Table 4.





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