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Fig. 7. Effects of quinidine on ventilation frequency in adult zebrafish. (A)
Zebrafish were exposed to 0.1 mmol l–1, 0.5 mmol
l–1 and 1 mmol l–1 quinidine in a
continuously perfused chamber. Bars represent the duration of quinidine
application at each concentration. While 0.1 mmol l–1
quinidine had no effect, the addition of 0.5 mmol l–1 and 1
mmol l–1 significantly increased (asterisks) ventilation
frequency (min–1; mean ±
S.E.M.) compared to the control
(N=6; P<0.05; ANOVA–Bonferroni test). This effect
was fully reversible. (B) Dose–response curve of data in A. Data points
from 2, 5, 8 and 11 min are plotted. Asterisks indicate a significant increase
from control (0 mmol l–1). N=6; P<0.05;
ANOVA–Bonferroni test.
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