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Fig. 7. A model of convergent neuropeptide DH31 (CLR) and DH44 (CRF-R) signaling pathways. DH31-R (red) and DH44-R (blue) signaling pathways are co-expressed by principal cells of the tubule (top), and onto CRZ-containing neurons of the CNS (bottom). Both pathways elicit cAMP increases; the DH31-R1 utilizes a RCP accessory protein. We show DH31 and DH44 neurons as distinct cell populations in this model (see Fig. S2 in supplementary material), but these may be partially overlapping. M. tubule, Malphigian tubule.





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