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Fig. 4. The p38 MAPK inhibitor SB203580 had no effect on current (A) compared to
the vehicle-treated membranes (Drug/Veh), but SB203580 significantly enhanced
the inhibition of current by hypotonic shock (HYPO) and significantly reduced
the recovery of current after restoration of isotonic conditions (ISO;
*P<0.05, paired t-test). The transepithelial
resistance (B) change mirrors the current changes, with SB203580 increasing
the resistance rise compared to vehicle (*P<0.05,
paired t-test) seen with hypotonic shock.
