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Fig. 3. Effect of NAD(P)H oxidase inhibitor (DPI) and superoxide dismutase mimetic (TEMPOL) on endothelin-1 (ET-1) stimulation of [Ca2+]i in shark vascular smooth muscle (VSM). (A) Typical tracing of the [Ca2+]i response to ET-1 in the presence and absence of DPI. (B) Typical tracing of the ET-1 in the presence and absence of TEMPOL. (C) Summary data showing the inhibitory effects of DPI (N=19) and TEMPOL (N=19) on the ET-1 induced elevation of [Ca2+]i. *P<0.01 for ET-1 plus DPI or TEMPOL vs ET-1 alone.





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