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Fig. 2. Effect of inhibitors of ADPR cyclase on endothelin-1 (ET-1)-stimulated increases in [Ca2+]i in vascular smooth muscle (VSM). (A) Representative tracing of the [Ca2+]i response to ET-1 in the presence and absence of nicotinamide. (B) Representative tracing of the response to ET-1 in the presence and absence of Zn2+. (C) Summary data of the effects of nicotinamide (N=15) and Zn2+ (N=11) on the ET-1-induced peak elevation of [Ca2+]i. *P<0.01 for both inhibitors vs ET-1 alone.





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