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Fig. 5. Survival curves of adult Drosophila maintained at 25°C. (A) Influence of heat shock on lifespan in the long-lived line. RMHS extended mean lifespan by 11.5% and maximum lifespan by 5.6%. (B) Influence of the HDAC inhibitor TSA on lifespan in the long-lived line. Only c.TSA extended mean lifespan by 15.6%. (C) Influence of HDAC inhibitor BuA on lifespan in long-lived line. BuA treatment had no obvious effect on both mean and maximum lifespan. (D) Influence of heat shock and the HDAC inhibitors TSA or BuA on lifespan in the long-lived line. There was no significant differences among RMHS, TSA-RMHS and BuA-RMHS treatments. (E) Influence of heat shock on lifespan in short-lived line. RMHS extended mean lifespan by 25.8% and maximum lifespan by 11.5%, respectively. (F) Influence of the HDAC inhibitor TSA on lifespan in the short-lived line. o.TSA slightly increased mean lifespan by 5%, and c.TSA increased mean lifespan by 24.4% and maximum lifespan by 16.4%. (G) Influence of the HDAC inhibitor BuA on lifespan in the short-lived line. Only o.BuA increased mean lifespan by 25.8% and maximum lifespan by 11.5%, respectively. (H) Influence of heat shock and HDAC inhibitor TSA or BuA on lifespan in short-lived line. No significant differences existed among RMHS, TSA-RMHS and BuA-RMHS treatments. Values shown are the means ± S.E.M. of four parallel experiments. con, control without any treatment; HS, 37°C one-off heat shock induced for 30 minutes only in larvae; RMHS, 32°C repeated mild heat shock for 1 h every 3 days until death; o.TSA, 10 µmol l^-1 TSA one-off treatment for 5 h only in larvae; c.TSA, continuous 10 µmol l^-1 TSA treatment until death; o.BuA, 10 mmol l^-1 BuA one-off treatment for 5 h only in larvae; c.BuA, continuous 10 mmol l^-1 BuA treatment until death.

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