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Fig. 4. Effects of symmetric anion substitution and apical addition of DPC on basal Isc. (A) Isc trace showing the inhibitory effects of 10 µmol l-1 and 100 µmol l-1 DPC on basal anion current in a tissue pretreated with 100 µmol l-1 amiloride. (B) Magnitude of basal Isc inhibition produced by apical DPC, 100 µmol l-1 (N=5), Cl- replacement with methane sulfonate (N=7), HCO3- replacement with Hepes (N=6) and 0.5 mmol l-1 DIDS added to the apical solution (N=5).





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