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Fig. 11. Effect of WIN 55,212-2 on the Na+ currents in the presence of an inhibitor of PKC. (A) Representative example of time course of the current signal. The currents were elicited by a pulse from a holding potential of –84 mV to a test potential of –24 mV. (B) Mean values of Na+ current magnitudes before (white bar) and after superfusion with 10 µmol l–1 chelerythrine and 10 µmol l–1 WIN 55,212-2 (hatched bar). Numerals within parentheses are number of the cells sampled. (C) Voltage dependence of activation. V1/2=–42.0 mV, k=–6.1 mV for control (open squares), V1/2=–30.7 mV, k=–8.0 mV for chelerythrine plus WIN 55,212-2 (filled circles). (D) Voltage dependence of inactivation. V1/2=–83.5 mV, k=8.4 mV for control (open squares), V1/2=–103.8 mV, k=7.6 mV for chelerythrine plus WIN 55,212-2 (filled circles). The values are mean ± S.E.M. obtained from three cells.





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