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Fig. 4. Effect of pymetrozine on the resistance reflex response in the extensor
tibiae motor nerve. (A,B) near-threshold concentration. (A) Sample recording
from the middle leg's extensor nerve (i) before and (ii) after application of
10–8 mol l–1 pymetrozine, during
ramp-and-hold stimulation of the fCO (bottom trace; stimulus amplitude 240
µm, or 
40°). (B) Peristimulus time histograms (PSTHs) were
constructed from the recording sample in A (i) before and (ii,iii) after
pymetrozine application (bin width 20 ms; ordinates normalised to number of
stimulus presentations, as in all following figures; stimulus, bottom trace).
The histogram in Bii was constructed from experiments where a tonic spike
discharge was observed after pymetrozine application (N=8), the
histogram in Biii from experiments without such tonic discharge
(N=2). (C,D) Effect of pymetrozine at higher concentrations
(10–5 mol l–1); same presentation as in A
and B. (C) Sample recording from the middle leg extensor nerve (i) before and
(ii) after pymetrozine application (stimulus, bottom trace). (D) PST
histograms constructed from the recordings (i) before and (ii) after
pymetrozine application (bin width 20 ms; stimulus, bottom trace). (E)
Increased stimulus amplitude [360 µm (60°); instead of 240 µm]
or (F) increased stimulus velocity (455 deg. s–1; instead of
45 deg. s–1) did not restore the feedback response abolished
by pymetrozine. Same recordings as in C and D, response before pymetrozine
application in Ci and Di.
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