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Fig. 12. Effects of p-glycoprotein (P-gp) inhibitors on secreted fluid concentration
of daunorubicin (A,B) or rhodamine 123 (C,D) for cricket tubules set up in
Ramsay assays. Each panel shows the flux (mean +
S.E.M.) for control tubules (filled bars)
exposed to the dye alone at the indicated concentration (µmol
l–1) and those treated with the same dye concentration and a
P-gp inhibitor at the concentration (µmol l–1) indicated
(open bars). Abbreviations: daunorubicin (DNR), verapamil (VRP), rhodamine 123
(R123); tetraethylammonium (TEA). Significant differences (P<0.05)
between control and experimental groups indicated by asterisks.
N=7–10 tubules for each bar.
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