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Fig. 10. Effects of the MRP2 inhibitors MK-571 and probenecid (PROB) on transepithelial flux of Texas Red across isolated Drosophila tubules set up in Ramsay assays. Each bar shows the flux (mean + S.E.M.) for 7–9 tubules (MK-571) or 10 tubules (probenecid) bathed in saline containing the indicated concentration (µmol l–1) of Texas Red in the absence (filled bars) or presence (open bars) of the indicated inhibitor. Asterisks indicate significant (P<0.05) decreases in flux in the presence of each drug, relative to the corresponding controls.





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