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Fig. 7. Mechanistic relationship between paired-pulse facilitation and
tetanus-induced augmentation for (A,B) a A5-3 neuron, a type of neuron
MB-extrinsic neuron that was characterized with respect to its branching
pattern and the location of its soma by Rybak and Menzel
(1993), and (C) a PE1 neuron.
(A,B) The A5-3 neuron was first stimulated by repeated paired pulses with
pulse intervals of 30 ms, then a tetanus (thick vertical line) was applied and
the paired pulses were continued (A). Afterwards the neuron was stimulated
with paired pulses with pulse intervals of 60 ms, then a tetanus was applied,
followed by a continuation of paired-pulse stimuli (B). Before the tetanus the
paired pulses caused a slight facilatory effect with little difference between
the repeated paired pulses of 30 ms and 60 ms. Responses to the second pulse
facilitated after the tetanus in the 
t=30 ms protocol, but not
in the t=60 ms protocol. (C) The PE1 neuron was first
stimulated with paired pulses at intervals of 30 ms, then tetanus was applied.
The facilatory effect of the tetanus is expressed in the responses to both the
first and the second pulse, and no change is found between paired pulse
facilitation before and after the tetanus. Filled circles, number of spikes
for the first stimulus in the paired pulses; open circles, those for the
second stimulus. The ordinate in the diagrams gives the number of spikes
elicited by a single stimulus, and the abscissa time in s.
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