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Fig. 4. Unidirectional secretory, unidirectional reabsorptive, and net urate fluxes by chick PTCs following treatment with methotrexate (500 µmol l–1) or MK571 (20 µmol l–1). Methotrexate (at t=–0.5 h) and MK571 (at t=0) were added to the interstitial or luminal sides of the epithelium. Data are presented as the percentage of the paired control secretory flux and are means ± S.E.M. of five preparations. *Significantly different from paired control flux (P<0.05, paired t-test).





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