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Fig. 4. Effects of bolus injections of ET-1 (120 pmol kg-1) before pharmacological manipulation and after infusion of ETB-antagonist (0.15 µmol kg-1) and tezosentan (15.4 µmol kg-1) on relative changes in haemodynamic variables. Data points show means ± S.E.M. for five individual experiments. Bars marked with different letters are significantly different from each other (P<0.05).





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