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Fig. 4. Multiple sequence alignment of DSX homologues from D. melanogaster, B. tryoni, M. domestica, M. scalaris, B. mori and A. gambiae. The sequence is divided into (A) the region that is common to DSXF and DSXM, (B) the conserved female-specific parts and (C) the highly divergent male-specific regions. The DBD/OD1 and OD2 domains are indicated. Black boxes represent areas of amino acid identity; gray boxes represent areas of amino acid similarity; the asterisks indicate six amino acids whose replacement has been shown to abolish DNA-binding activity in D. melanogaster.





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