|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 9. Schematic representation of hypothetical paracrine actions of the anterior
commissural organ (ACO) in the commissural ganglion (CoG). In addition to
serving as a source of CabTRP Ia to the hemolymph, some portions of the ACO
terminate directly on areas of synaptic neuropil, and this structure may thus
also function as a paracrine modulator of intrinsic CoG targets. One potential
role for this paracrine signaling is the coordination of multiple
neuroendocrine systems. The soma of the large (L)-cell, which projects to and
innervates the pericardial organ (PO), is located within the CoG and is known
to arborize in the vicinity of the ACO. Likewise, anterior commissural neurons
1 and 2 (ACN1/2), which are the sole source of innervation to the anterior
cardiac plexus (ACP), are also located in the CoG and arborize near the ACO.
If these neurons are modulated by CabTRP Ia, then elements of at least two
other neuroendocrine centers could be modulated/synchronized locally within
the CoG, concurrent with the release of CabTRP Ia from the ACO into the
circulatory system. Non-endocrine neurons within the CoG [specifically CoG
projection neurons (CPN) that innervate and modulate the stomatogastric neural
circuit] may also be targets of paracrine signals from the ACO. If these
neurons are influenced by CabTRP Ia released from the ACO, then a profound
reorganization of the motor patterns produced by the motor neurons (MN) of the
circuits contained within the stomatogastric ganglion could occur.
Abbreviations not defined in this legend are as per
Fig. 1.
|
