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Fig. 11. Anoga-DH31 has natriuretic activity in tubules previously challenged with Musdo-K. Fluid secretion and urine Na+ and K+ concentrations were measured over 30 min intervals under control conditions and after the addition of 1 µmol l–1 Musdo-K alone and then in combination with 1 µmol l–1 Anoga-DH31. Bars represent the means + S.E.M. for eight tubules. Fluid secretion (open bars) is stimulated 4-fold by Musdo-K, but the urine [Na+]:[K+] ratio (solid bars) is unchanged. Both parameters are increased >6-fold after the addition of Anoga-DH31. Identical letters indicate values that do not differ significantly (P>0.05).





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