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Fig. 6. Comparison of amino acid sequences in domain IV of `typical' calpains from arthropods and human. Deduced amino acid sequences were aligned using ClustalW (see Materials and methods). Broken lines indicate gaps for optimizing alignment. Amino acid residues that are identical or similar in all the sequences are highlighted in black; gray background indicates identical or similar amino acids in most of the sequences. Numbers at the right indicate amino acid positions, numbered from the N-terminus of each protein. Domain IV is a calmodulin-like domain that contains five EF-hand motifs (boxes with broken line). Dm-CalpA contains a unique insertion sequence between EF-1 and EF-2. The putative EF-5 region was the least conserved between the calpain sequences. Accession numbers are the same as those given in the legend to Fig. 5.





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