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Fig. 3. Simulated muscle fibres are able to support spikes in response to rapid
depolarizations (A; black trace), which is enhanced when successive stimuli
are separated by a hyperpolarizing interval (A; red trace). (B) The rate of
recovery of the graded action potentials in response to the second
depolarization is faster when the cell is hyperpolarized by injecting 0.7 nA
of current during the interstimulus interval (red traces) than when no current
is injected (black traces). (C) A recording of the value of the sodium
inactivation variable, h, between two depolarizing stimuli separated
by an interval of 1 ms shows that h recovers more effectively when 2
nA of hyperpolarizing current is injected during the interstimulus interval
(red trace) compared with `control' (black trace). (D) If, however, the value
of h between the paired stimuli against an interpulse potential of
–70 mV is adjusted to the value that is recorded at the same time but
against an interpulse potential of –90 mV (red trace), the recovery of
the second action potential matches that obtained against a resting potential
of –90 mV.
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