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Fig. 7. The serial effects of
-CTx AuIB and
-CTx MII are also
additive, suggesting that
3ß2- and
3ß4-nAChRs can
exist as independent entities in submucosal neurones. (A) High-resolution
image of a submucosal ganglion (inverted grey scale), showing the individual
neurones identified by numbers. The position of the stimulation electrode is
shown schematically. (B) Pixel map of the NeuroCCD-SM camera depicting, in
red, the area of interest. (C) Experimental protocol. (D) Spatially averaged
optical outputs from the red pixels in B (represented by bars whose heights
indicate the amplitude of the voltage change under each experimental condition
in the row labelled `Ganglion') and from selected individual neurones
(`Cells'). Magnification, 100x. `Ganglion' signals were high-pass
filtered at 6.6 Hz. `Cell' traces were low-pass filtered at 200 Hz.